Self-medication with antibiotics: identification of risk factors and analysis of the brazilian population’s lifestyle.

Clea Adas Saliba Garbin, Julia Arruda Batista, Bruno Wakayama, Artenio Jose Saliba Garbin, Artenio Jose Isper Garbin, Orlando Adas Saliba Junior

Resumo


Objectives:Measure the prevalence of adult and elderly users of the Brazilian primary healthcare system who self-medicated with antibiotics and identified its association with risk factors for self-medication and lifestyle. 

Materials and Methods:This is a quantitative, epidemiological study carried out in the Brazilian primary healthcare system. We used a semi-structured questionnaire and the Fantastic Lifestyle Checklist. We carried out a bivariate analysis, a binomial logistic regression, and the Mann-Whitney nonparametric test.

Results: Out of the total sample (537 participants), 40.6% used antibiotics without medical prescription in the last 12 months. The dependent variable was associated with the presence of pain (OR=2.390, CI95, 1.414-4.041); storage of leftover antibiotics in the home (OR=2.124 CI95, 1.122-4.021); and use of medicines on someone’s recommendation (OR=1.722, CI95, 1.127-2.631). The group of individuals who used antibiotics without prescription in the last year had the lowest values in all domains assessed by the Fantastic Lifestyle Checklist and had the highest proportions in the final score of “Fair" and "Needs improvement”.

Conclusions: A significant proportion of primary health care users in Brazil used antibiotics without medical prescription. Therefore, the population should receive better guidance on the use of antibiotics and greater incentive to develop healthy habits and lifestyle.


Palavras-chave


Automedicação; Farmacoresistência bacteriana; Estilo de vida.

Texto completo:

PDF (English)

Referências


Alhomoud F, Aljamea Z, Almahasnah R, Alkhalifah K, Basalelah L, Alhomoud FK. Self-medication and self-prescription with antibiotics in the Middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. Int J Infect Dis 2017; 57: 3-12.

World Health Organization. Guidelines for the regulatory assessment of medicinal products for use in self-medication. Geneva, Switzerland: World Health Organization; 2000.

Napolitano F, Izzo MT, Di Giuseppe G, Angelillo IF. Public knowledge, attitudes, and experience regarding the use of antibiotics in Italy. PLoS One 2013;8:e84177.

Torres NF, Chibi B, Middleton LE, Solomon VP, Mashamba-Thompson T. Evidence of factors influencing self-medication with antibiotics in LMICs: a systematic scoping review protocol. Syst Rev 2018; 7: 102.

Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. Atlanta, GA: CDC; 2013.

World Health Organization. No time to wait: securing the future from drug‐resistant infections. Geneva, Switzerland: World Health Organization; 2019

World Health Organization. WHO report on surveillance of antibiotic consumption 2016–2018 early implementation. Geneva, Switzerland: World Health Organization; 2018.

Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis 2011; 11: 692-701.

Ocan M, Obuku EA, Bwanga F, Akena D, Richard S, Ogwal-Okeng J, et al. Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health 2015; 15: 742.

Jamhour A, El-Kheir A, Salameh P, Hanna PA, Mansour H. Antibiotic knowledge and self-medication practices in a developing country: a cross-sectional study. Am J Infect Control 2017; 45: 384–388.

Servia-Dopazo M, Figueiras A. Determinants of antibiotic dispensing without prescription: a systematic review. J Antimicrob Chemother 2018; 73: 3244–3253.

Portes LA. Estilo de vida e qualidade de vida: semelhanças e diferenças entre os conceitos. Lifestyle J 2011; 1: 8-10.

Campagne DM. Accountability for an unhealthy lifestyle. Eur J Health Econ. 2020

World Health Organization. A glossary of terms for community health care and services for older persons. Geneva, Switzerland: World Health Organization; 2004.

Zadeh NK, Robertson K, Green JA. Lifestyle determinants of behavioural outcomes triggered by direct-to-consumer advertising of prescription medicines: a cross-sectional study. Aust N Z J Public Health 2019; 43: 190–196.

Lawrence EM, Mollborn S and Hummer RA. Health lifestyles across the transition to adulthood: Implications for health. Soc Sci Med 2017; 193: 23-32.

Soares MF, Ferreira RC, Pazzini CA, Travassos DV, Paiva SM, Ferreira EF. Individual and collective empowerment and associated factors among Brazilian adults: a cross-sectional study. BMC Public Health 2015; 15: 775.

Wilson DM, Nielsen E, Ciliska D. Lifestyle assessment: testing the FANTASTIC instrument. Can Fam Physician 1984; 30: 1863-1866.

Añez CRR, Reis RS, Petroski EL. Versão brasileira do questionário "estilo de vida fantástico": tradução e validação para adultos jovens. Arq Bras Cardiol 2008; 91: 102-108.

Zoorob R, Grigoryan L, Nash S, Trautner BW. Nonprescription antimicrobial use in a primary care population in the United States. Antimicrob Agents Chemother 2016; 60: 5527-5532.

Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES. Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique. PLoS One 2019 ; 14: e0221452.

Tomas A, Kusturica M, Tomić Z, Horvat O. Self-medication with antibiotics in Serbian households: a case for action? Int J Clin Pharm. 2017;39:507-513.

Mazińska B, Strużycka I, Hryniewicz W. Surveys of public knowledge and attitudes with regard to antibiotics in Poland: did the european antibiotic awareness day campaigns change attitudes? PLoS One 2017 ; 12: e0172146.

Kamata K, Tokuda Y, Gu Y, Ohmagari N, Yanagihara K. Public knowledge and perception about antimicrobials and antimicrobial resistance in Japan: A national questionnaire survey in 2017. PLoS One. 2018;13(11):e0207017.

Nounou B, Cattáneo ME, Salmón R, Palasezze L, Boccaleri J, Cestona E, et al. A study regarding consumption and self-medication with antibiotics in the city of La Plata (Buenos Aires, Argentina). Lat Am J Pharm 2009; 28: 544-551.

Zajmi D, Berisha M, Begolli I, Hoxha R, Mehmeti R, Mulliqi-Osmani G, et al. Public knowledge, attitudes and practices regarding antibiotic use in Kosovo. Pharm Pract 2017; 15: 827.

World Health Organization. Antimicrobial resistance: global report on surveillance, 2014. Geneva, Switzerland: World Health Organization; 2014.

Llor C, Bjerrum, L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 2014; 5: 229–241.

Santa-Ana-Tellez Y, Mantel-Teeuwisse AK, Dreser A, Leufkens HG, Wirtz VJ. Impact of over-the-counter restrictions on antibiotic consumption in Brazil and Mexico. PLoS One 2013; 6; e75550.

Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução-RDC nº 44, de 26 de outubro de 2010. Dispõe sobre o controle de medicamentos à base de substâncias classificadas como antimicrobianos, de uso sob prescrição médica, isoladas ou em associação e dá outras providências. https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2010/res0044_26_10_2010.html

Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução – RDC nº 20, de 5 de maio de 2011. Dispõe sobre o controle de medicamentos à base de substâncias classificadas como antimicrobianos, de uso sob prescrição, isoladas ou em associação. https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2011/rdc0020_05_05_2011.html

Gualano MR, Gili R, Scaioli G, Bert F, Siliquini R. General population's knowledge and attitudes about antibiotics: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2015; 24: 2–10.

Voidăzan S, Moldovan G, Voidăzan L, Zazgyva A, Moldovan H. Knowledge, attitudes and practices regarding the use of antibiotics. study on the general population of mureş county, Romania. Infect Drug Resist. 2019; 12: 3385–3396.

Almohammed RA, Bird EL. Public knowledge and behaviours relating to antibiotic use in Gulf Cooperation Council countries: a systematic review. J Infect Public Health 2019; 12: 159–166.

Lum EPM, Page K, Nissen L, Doust J, Graves N. Australian consumer perspectives, attitudes and behaviours on antibiotic use and antibiotic resistance: a qualitative study with implications for public health policy and practice. BMC Public Health 2017; 17: 799.

Vacher R, Lagarce L, Ghamrawi S, et al. (2020) Drug interactions related to self-medication: a French pharmacovigilance database study. Fundam Clin Pharmacol. Epub ahead of print 16 Feb 2020.

Farhud DD. Impact of lifestyle on health. Iran J Public Health 2015; 44: 1442–1444.

Zaman R, Hankir A, Jemni M. Lifestyle factors and mental health. Psychiatr Danub 2019; 3: 217–220.

Burdette AM, Needham BL, Taylor MG, Hill TD. Health lifestyles in adolescence and self-rated health into adulthood. J Health Soc Behav 2017; 58: 520–536.

Pôrto EF, Kümpel C, Castro AAM, Oliveira IM, Alfieri FM. How life style has been evaluated: a systematic review. Acta Fisiatr 2015; 22: 199-205.

Riediger ND, Bombak AE , Mudryj AN. Health-related behaviours and their relationship with self-rated health among Canadian adults. BMC Public Health 2019; 19: 960.

Santos ZMSA, Lima HP. Educacional health technology in arterial hypertension prevention in workers : Lifestyle change analysis. Texto Contexto – Enferm 2008; 17: 90-97.

Ramírez-Vélez R, Agredo RA. The Fantastic instrument’s validity and reliability for measuring Colombian adults’ life-style. Rev Salud Pública 2012; 14: 226-237.




DOI: http://dx.doi.org/10.18316/sdh.v9i3.7668

Apontamentos

  • Não há apontamentos.


e-ISSN: 2317-8582

UNILASALLE - Av. Victor Barreto, 2288 Centro Canoas/RS Cep: 92.010-000