Pharmacological Therapies For Polycystic Ovary Syndrome Alternative To Hormone Therapies
An Integrative Review
DOI:
https://doi.org/10.18316/sdh.v12i3.11029Keywords:
Polycystic ovary syndrome, Drug therapy, EfficacyAbstract
Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine pathology in women of reproductive age and its pathophysiology is associated with insulin resistance, increased risk for cardiovascular disease, obesity, depression and infertility. Objective: To explain current and relevant information available in the literature on drugs used in the treatment of PCOS and alternatives to the use of hormonal contraceptives, regarding their effects, efficacy and safety. Materials and methods: This is an integrative literature review based on the search for articles published between 2017 and 2022 in the electronic databases PubMed, EMBASE and SCIELO. The selection criteria and analysis process were guided by the PRISMA 2020 flowchart. Results: 10 randomized clinical trials were selected, citing 13 drugs from different pharmacological classes. The drugs mentioned were: metformin, empagliflozin, dapagliflozin, canagliflozin, liraglutide, exenatide, saxagliptin, pioglitazone, clomiphene hydrochloride, amlodipine, fezolinetant, phentermine and topiramate. Conclusion: Most of the drugs presented in this review demonstrated similar effectiveness and many times superior to the drug commonly used in PCOS, metformin. They also demonstrated broader therapeutic effects than oral hormonal contraceptives. In general, they were well tolerated and had mild or moderate adverse effects.
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