The Impact of Abstinence on Serum Leptin Levels and on the Nutritional Profile of Alcoholics

Authors

DOI:

https://doi.org/10.18316/sdh.v11i2.9742

Keywords:

Transtorno do Abuso de Álcool, Composição Corporal, Estado Nutricional, Índice de Massa Corporal, Leptina.

Abstract

Introduction: Alcohol use disorder (AUD) is associated with changes in metabolism and in the nutritional profile. Food-seeking behaviors and psychoactive substances share common biological pathways that activate the reward system and leptin is a modulator of this system. Objective: To measure serum leptin levels and nutritional status of individuals with before their detoxification and then 15 days later. Methods: In total, 38 men diagnosed with AUD and admitted to a detoxification unit were analyzed. Serum leptin levels, Body Mass Index (BMI), Waist Circumference (WC) and body composition were assessed by Bioelectrical Impedance Analysis (BIA) once within the first 48 hours of hospital admission and again 15 days after the first assessment. Results: Weight, BMI and WC increased significantly during detoxing (p<0.001), but body fat and leptin levels percentages remained similar. At admission, leptin levels were positively correlated with body fat (0.607), WC (0.696), and BMI (0.357). After 15 days, only leptin and BMI were significantly correlated (0.462). Conclusion: Our results reinforce the relationship between leptin and nutritional parameters related to body weight. It is essential to educate about nutrition and to encourage healthy eating behaviors so individuals with AUD can reduce weight gain during the recovery period.

Author Biographies

Laíse Balbinotti, Hospital de Clinicas de Porto Alegre

Nutritionist at Hospital de Clínicas de Porto Alegre, Master in Food, Nutrition and Health - PPGANS-UFRGS.

Jaqueline Schuch, Hospital de Clinicas de Porto Alegre

Biomedical, Postgraduate Postdoctoral Student of the Program in Psychiatry and Behavioral Sciences

Daiane dos Santos Ferreira, Hospital de Clinicas de Porto Alegre

Researcher at the Center for Research on Alcohol and Drugs (CPAD) at Hospital de Clínicas de Porto Alegre (HCPA).

Mariana Escobar, Hospital de Clinicas de Porto Alegre

Nutritionist at Hospital de Clínicas de Porto Alegre, Master in Biochemistry and PhD in Psychiatry - Postgraduate Program in Psychiatry and Behavioral Sciences -UFRGS

Juliane V. Feldman, Grupo Hospitalar Conceição (GHC)

Nutritionist, Specialist in Comprehensive Care for Drug Users / Mental Health (HCPA), Family and Community Health Resident (GHC)

Gabriele C. Forte, Hospital de Clinicas de Porto Alegre

Nutritionist at Hospital de Clínicas de Porto Alegre, Ph.D. in Pulmonary Sciences and post-doctorate in Pediatrics and Child Health-UFRGS

Lisia von Diemen, Postgraduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul

Psychiatrist, Ph.D. in psychiatry, Professor at the Department of Psychiatry and Legal Medicine at UFRGS, Professor at the Postgraduate Program in Psychiatry and Behavioral Sciences at UFRGS, Vice-Director at the Center for Research on Alcohol and Drugs at UFRGS/HCPA

Anne O. Sordi, Hospital de Clinicas de Porto Alegre

Psychiatrist, Ph.D. in psychiatry, Head of the Addiction Treatment Unit of Hospital de Clinicas de Porto Alegre

Martine Kienzle Hagen, Universidade Federal do Rio Grande do Sul

Nutritionist, Master in Biochemistry, and Ph.D. in Physiology, Professor at the Department of Nutrition and Professor at the Postgraduate Program in Food, Nutrition, and Health at the Federal University of Rio Grande do Sul.

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2023-06-22

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Vol. 11 No. 2 (2023)

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