STABLE MICROBUBBLE TEST IN THE EARLY DIAGNOSIS OF NEWBORN RESPIRATORY DISTRESS SYNDROME
DOI:
https://doi.org/10.18316/sdh.v12i1.10842Palabras clave:
Stable Microbubble Test, Respiratory distress syndrome, Newborns, Exogenous surfactant, Corticosteroid therapy.Resumen
Objective: To analyze the importance of SMT in the early diagnosis of NRDS in newborns (NB) with gestational age between 32 and 37 weeks with respiratory distress. Methodology: observational, cohort study. Data collection occurred in a public hospital in southern Brazil between March 2018 and February 2020. Results: The groups of patients with and without respiratory distress were compared in relation to the number of stable microbubbles. Among the NBs with respiratory distress (RD), 50% presented between 15 and 50 SM/mm² and 50% above 50 SM/mm². On the other hand, 18% of the patients without RD presented between 15 and 50 SM/mm², while 82% presented more than 50 SM/mm², with no significant difference or association. The mothers of NBs with RD received pre-delivery corticosteroid therapy, a protective factor for developing NRDS, not requiring the administration of exogenous surfactant. Conclusion: using the SMT to aid in the diagnosis of NRDS was an effective method since there was no NB with less than 15 SM/mm² and no NB required exogenous surfactant. Certainly, the amount greater than 15 SM/mm² in NB with respiratory distress accuses moderate or severe SDRRN, which does not require administrating exogenous surfactant.
Citas
Rotinas Assistenciais da Maternidade-Escola da Universidade Federal do Rio de Janeiro [Internet]; 2011. Síndrome do desconforto respiratório (SDR); [cited 2021 Jan 3]; Available from: http://www.me.ufrj.br/images/pdfs/protocolos/neonatologia/sindrome_do_desconforto_respiratorio.pdf
Ruschel L, Nader PJH. A doença da membrana hialina em prematuros de baixo peso. Rev. AMRIGS. 2014 jul-set;58:193-197.
Seitz EE, Fiori HH, Luz JH, Fiori RM: Stable Microbubble Test on Tracheal Aspirate for the Diagnosis of Respiratory Distress Syndrome. Biol Neonate 2005;87:140-144. doi: 10.1159/000083126
Nilsson R, Grossmann G, Robertson B. Artificial ventilation of premature newborn rabbits: effects of positive end-expiratory pressure on lung mechanics and lung morphology. Acta Paediatr Scand. 1980 Sep;69(5):597-602. doi: 10.1111/j.1651-2227.1980.tb07328.x.
Balest AL [Internet]. Síndrome de dificultad respiratoria (síndrome de distrés respiratorio) en recién nacidos; 2021 Julho. [cited 2021 Jan 3]; Available from: https://www.msdmanuals.com/es/hogar/salud-infantil/problemas-pulmonares-y-respiratorios-en-reci%C3%A9n-nacidos/s%C3%ADndrome-de-dificultad-respiratoria-s%C3%ADndrome-de-distr%C3%A9s-respiratorio-en-reci%C3%A9n-nacidos
Lliodromiti Z, Zygouris D, Sifakis S, Pappa KI, Tsikouras P, Salakos N, Daniilidis A, Siristatidis C, Vrachnis N. Acute lung injury in preterm fetuses and neonates: mechanisms and molecular pathways. J Matern Fetal Neonatal Med. 2013 Nov;26(17):1696-704. doi: 10.3109/14767058.2013.798284. Epub 2013 May 20. PMID: 23611524
Rhinow AC [Internet]. Síndrome do desconforto respiratório do recém-nascido. 2020 [cited 2021 Jan 3]; Available from: https://vitallogy.com/feed/Sindrome+do+desconforto+respiratorio+do+recem-%20nascido/1377
Perez-Gil J, Weaver TE. Pulmonary Surfactant Pathophysiology: Current Models and Open Questions. PHYSIOLOGY [Internet]. 2010 [cited 2021 Jan 3];25:132-141. Available from: https://journals.physiology.org/doi/epdf/10.1152/physiol.00006.2010
Clements JA, Platzker ACG, Tierney DF, Hobel CJ, Creasy RK, Margolis AJ, Thibeault DW, Tooley WH, Oh W. Assessment of the Risk of the Respiratory-Distress Syndrome by a Rapid Test for Surfactant in Amniotic Fluid. N Engl J Med. 1972 May 18;286:1077-1081.
Chida, S, Fujiwara, T, Konishi, M. et al. Stable microbubble test for predicting the risk of respiratory distress syndrome: II. Prospective evaluation of the test on amniotic fluid and gastric aspirate. Eur J Pediatr 152, 152–156 (1993). https://doi.org/10.1007/BF02072494
Batista C, Taborda A, Bastos V, Abreu C, Lopes F, Reis A, Fonseca J. Pneumonia no período neonatal. Rev Port Pneumol [Internet]. 2000 Março/Abril [cited 2021 Jan 3];VI:163-167. Available from: https://www.revportcardiol.org/pt-pdf-S0873215915308813
Duke T. Neonatal pneumonia in developing countries. Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F211-9. doi: 10.1136/adc.2003.048108
Booth G R, Al-Hosni M, Ali A, Keenan W J. The utility of tracheal aspirate cultures in the immediate neonatal period. J Perinatol. 2009 Apr 02;29:493-496.
Fiori HH, Henn R, Baldisserotto M, Bica IG, Fiori RM. Evaluation of surfactant function at birth determined by the stable microbubble test in term and near term infants with respiratory distress. Eur J Pediatr. 2004 Aug;163(8):443-8. doi: 10.1007/s00431-004-1473-2. Epub 2004 Jun 8. PMID: 15185148.
Ribeiro MAS. Teste das microbolhas estáveis no aspirado bucal de recém-nascidos prematuros para o diagnóstico de síndrome do desconforto respiratório [Tese de Doutorado on the Internet]: Pontifícia Universidade Católica Do Rio Grande Do Sul; 2016 [cited 2021 Jan 3]. 87 s. Available from: https://tede2.pucrs.br/tede2/bitstream/tede/6992/2/TES_MANOEL_ANTONIO_DA_SILVA_RIBEIRO_PARCIAL.pdf
Cloherty JP, Eichenwald EC, Hansen AR, Stark AR. Manual of neonatal care [Internet]. 7th ed. 2015 [cited 2021 Jan 3]. Available from: http://www.ypeda.com/attachments/article/150/manual%20of%20neonatal%20care%207th.pdf
Pereira MS, Luz DCM, Rivero RED, Alencar MF, Gómez SC, Naccha GLB, Rensi AMV, Mendes AFM, Souza CMF, Amorim MRCF, Amorim ALC, Khouri PBS, Druzian LA. Teste das microbolhas estáveis no líquido amniótico de recém-nascidos prematuros para predição da maturidade pulmonar. Archives Of Health Investigation, 2018,7(2). doi: https://doi.org/10.21270/archi.v7i2.2605
Brasil. Ministério da Saúde. Resolução Nº 466, de 12 de dezembro de 2012. [citado em 28 de janeiro de 2021]. Disponível em: https://bvsms.saude.gov.br/bvs/saudelegis/cns/2013/res0466_12_12_2012.html
Pattle RE, Kratzing CC, Parkinson CE, Graves L, Robertson RD, Robards GJ, Currie JO, Parsons JH, Sutherland PD. Maturity of fetal lungs tested by production of stable microbubbles in amniotic fluid. Br J Obstet Gynaecol. 1979 Aug;86(8):615-22. doi: 10.1111/j.1471-0528.1979.tb10823.x.
Ribeiro MA, Fiori HH, Luz JH, Garcia PC, Fiori RM. Rapid diagnosis of respiratory distress syndrome by oral aspirate in premature newborns. J Pediatr (Rio J). 2019;95:489---94.
Daniel IWBS. Testes rápidos de maturidade pulmonar no aspirado gástrico de recém-nascidos prematuros para o diagnóstico de síndrome do desconforto respiratório [Dissertação de Mestrado on the Internet].: Pontifícia Universidade Católica Do Rio Grande Do Sul; 2008 [cited 2021 Jan 3]. 103 p. Available from: https://repositorio.pucrs.br/dspace/bitstream/10923/4627/1/000405622-Texto%2BCompleto-0.pdf
Verdum G. Valor do teste de microbolhas estáveis para a predição de necessidades de segunda dose de surfactante em prematuros com menos de 32 semanas de idade gestacional [Dissertação de Mestrado on the Internet]. [place unknown]: Pontifícia Universidade Católica Do Rio Grande Do Sul; 2008 [cited 2021 Jan 3]. 71 s. Available from: https://repositorio.pucrs.br/dspace/bitstream/10923/4669/1/000402198-Texto%2BCompleto-0.pdf
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